REACH - CHEMICALS

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CHEMICALS - REACH

Responsibles :

The new European Chemicals regulation (REACH) was adopted in December 2006.
REACH stands for Registration, Evaluation, Authorisation and Restriction of Chemicals. REACH Regulation (EC) No 1907/2006 and Directive 2006/121/EC amending Directive 67/548/EEC were published in the Official Journal on 30 December 2006.
REACH will enter into force on 1 June 2007. Enterprises which manufacture or import more than one tonne of a chemical substance per year will be required to register it in a central database administered by the new EU Chemicals Agency.
REACH will require a registration, over a period of 11 years, of some 30.000 chemical substances. The registration process requires the manufacturers and importers to generate data for all chemicals substances produced or imported into the EU above one tonne per year. The registrants must also identify appropriate risk management measures and communicate them to the users.
The onus will move from the authorities to industry. In addition, REACH will allow the further evaluation of substances where there are grounds for concern and foresees an authorisation system for the use of substances of very high concern. This applies to substances that cause cancer, infertility, genetic mutations or birth defects, and to those which are persistent and accumulate in the environment. The Authorisation system will require companies to switch progressively to safer alternatives where a suitable alternative exists. All applications for an authorisation need to include an analysis of alternatives and a substitution plan where a suitable alternative exists. Current use restrictions will remain under REACH system.
Useful links : http://ec.europa.eu/enterprise/reach/index_en.htm

Scientific Articles :
1.	Hazard classification of chemicals inducing haemolytic anaemia : An EU Regulatory perspective. Muller,A; Jacobsen,H.; Healy,E; McMickan,S; Istace,F.; Blaude,M-N; Howden,P; Fleig,H & Schulte,A. (2006) Regul. Toxicol. Pharmacol., 2006, 45, 3, 229-241
2.	Study of the interference problems of dioxin-like chemicals with the bio-analytical method "CALUX" Carmen Schroijen, Isabelle Windal, Leo Goeyens, Willy Baeyens Talanta, 2004, , , 1261-1268
3.	Improved prediction of the human acute toxicity by the delayed cytotoxicity of the MEIC reference chemicals in Fa32 cells. P.J. Dierickx Toxicol. Lett. , 2003, 144, (S1), s48
4.	Comparison of the cytotoxicity of the MEIC reference chemicals measured in PBS and in complete medium. P.J. Dierickx 21st Annual SSCT Workshop on In Vitro Toxicology, Murikka, Finlan; Book of abstracts, 2003, , , p.52
5.	Correlation between the delayed cytotoxicity of the MEIC reference chemicals in Fa32 cells and human acute toxicity. P.J. Dierickx Beltox annual meeting 2002 : Current trends in chemical risk assessment, Brussel; Book of abstracts, 2002, , , P-15
6.	Correlation between the delayed cytotoxicity of the MEIC reference chemicals and human acute toxicity. P.J. Dierickx 12th International Workshop on In Vitro Toxicology, Formia (Italy); Book of abstracts, 2002, , , PB-02
7.	Trace Contamination with Dioxin-like Chemicals in Feed and Food Substances: Evaluation of the TEQ Determination for Risk Assessment and Regulatory Responses I. Van Overmeire, G.C. Clark, D. Brown, M.D. Chu, W.M. Cooke, M.S. Denison, W. Baeyens, S. Srebrnik, L. Goeyens Environmental Science & Policy, 2001, 4, , 345-357
8.	Long-term in vitro toxicity of 27 MEIC chemicals on HepG2 cells. E.M. Scheers, Ba. Ekwall and P.J. Dierickx Alt. Lab. Anim. , 2001, 29, , 279-299
9.	Cytotoxicity of the MEIC reference chemicals in anti-oxidant enriched rat hepatoma-derived Fa32 cells. P.J. Dierickx, C. Smit and E.M. Scheers Alt. Lab. Anim. , 2001, 29, , 217-223
10.	Cytotoxicity of the MEIC reference chemicals in cultured rat hepatoma-derived Fa32 cells. P.J. Dierickx Hum. Exp. Toxicol., 2001, 20, , 56
11.	In vitro long-term cytotoxicity testing of 27 MEIC chemicals and comparison with acute human toxicity data. E.M. Scheers, Ba. Ekwall and P.J. Dierickx Toxicol. In vitro , 2001, 15, , 153-161
12.	Cytotoxicity of the MEIC reference chemicals in rat hepatoma-derived Fa32 cells. P.J. Dierickx Toxicology , 2000, 150, , 159-169
13.	Effect of solubility, pH and isoforms on the acute cytotoxicity of chemicals. E.M. Scheers and P.J. Dierickx. Arch. Physiol. Biochem. , 2000, 110, , B15
14.	Neutral red uptake inhibition by the MEIC reference chemicals in antioxidant enriched Fa32 cells. P.J. Dierickx, C.Smit and E.M. Scheers 18th SSCT Annual workshop on in vitro toxicology, Sollentuna, Zweden ; Book of abstracts, 2000, , , 4
15.	In vitro long-term cytotoxicity of 27 chemicals on Hep G2 cells and comparison with acute human toxicity data. Scheers E.M. Ba. Ekwall and Dierickx P.J. 18th SSCT Annual workshop on in vitro toxicology, Sollentuna, Zweden ; Book of abstracts , 2000, , , 7
16.	In vitro long-term cytotoxicity of 27 MEIC chemicals on HepG2 cells compared to their acute human toxicity. E.M. Scheers, Ba Ekwall and P.J. Dierickx 11th International Workshop on in vitro toxicology, Acantilado, Spanje ; Book of abstracts , 2000, , , P5-04
17.	Cytotoxicity of the MEIC reference chemicals in Fa32 cells. P.J. Dierickx 11th International Workshop on in vitro toxicology, Acantilado, Spanje ; Book of abstracts , 2000, , , P1-02
18.	MEIC evaluation of acute systemic toxicity. Part IV. In Vitro results from 67 toxicity assays used to test reference chemicals 31-50 and a comparative cytotoxicity analysis. C.Clemedson et al. Alt. Lab. Anim. , 1998, 26, Suppl. I, , 131-183
Reports:
1.	An information system on dangerous chemicals and pesticides M. Martens, L. Hulsen, J. Aerts and G. Jacobs REF: D/2505/1982/34, 1982


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