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Welcome Directions Who's Who in the IPH A B C D E F G H I J K L M N O P Q R S T U V W X Y Z   (English search!) Please type a Keyword or a part of a keyword. If you type only 1 or 2 characters you will get a list of all keywords beginning with those characters. If you type a word of 3 or more characters you will get a list of all keywords containing that word anywhere in it. If any keyword was found, the right-most character of the searchstring is amputated and the search is repeated until a matching keyword is found. Download the "Who's Who in the IPH" list (.XLS file) ALTERNATIVE METHODS - TOXICOLOGY IN VITRO   Responsibles :   Troisfontaines, Paul Toxicology Tel: +32 2 642 5386 Verschaeve, Luc Toxicology Tel: +32 2 642 5436 Optimization and adaptation of an in vitro strategy for the assessment of human toxicity of nanoparticles. Manufactured nanomaterials and nanoparticles represent an emerging technological sector with more and more applications (microelectronics, coatings, textiles, sport goods, cosmetics, pharmaceutical applications, food industry applications…) As a spectacular augmentation of the professional and public exposure to nanomaterials is expected, we have to develop our knowledge of the toxicity of these materials. It appears that at this scale, the size matters as well as the chemical properties when it comes to describe the properties of the material and its interactions with living cells. Indeed, the nanoparticles and the nanoscaled materials show a huge surface area / mass ratio, conferring specific properties to them, and, the small size of the nanoparticles facilitates their uptake by cells and the passage across epithelial or endothelial barriers into the blood or the lymph circulation, from where they can reach internal organs. The aim of this project is to contribute to the evaluation of the potential harmful effects of the nanoparticles on human health by studying the cellular mechanisms involved in vitro.   Related pages in this site Research project in nanotoxicology Scientific Articles :  1.   European Union support for a Turkish reproductive health project to assess alternative cervical cancer screening methods in Sanliurfa (rural South-East Turkey). Arbyn M, Tulunay G, Ozgul N, Yalvak S, Verguts J, Poppe W, Sankaranarayanan R.  Eur J Cancer Prev ,  2006, 15,  , 552-3 2.   The use of fish cells in ecotoxicology. The report and recommendations of ECVAM workshop 47. Castano, A., Bols, N., Braunbeck, T., Dierickx, P., Halder, M., Isomaa, B., Kawahara,K., Lee, L.E.J., Mothersill, C., Pärt, P., Repetto, G., Sintes, J.R., Rufli, H., Smith, R., Wood, C. and Segner, H.  Alt. Lab. Anim.,  2003, 31,  , 317-351 3.   The prediction of human acute systemic toxicity by the EDIT/MEIC in vitro test battery : importance of protein binding and of partitioning into lipids. Clemedson, C., Dierickx P.J. and Sjöström, M.  Alt. Lab. Anim.,  2003, 31,  , 245-256 4.   The role of oxidative stress on the effect of 1,4,7,10,13,16-hexathiacyclo-octadecane on copper and zinc toxicity in Hep G2 cells. P.W. Smet, M. Elskens, F. Bolle, P.J. Dierickx  Human Exp. Toxicol.,  2003, 22,  , 89-93 5.   Evidence for delayed cytotoxicity effects following exposure of rat hepatoma-derived Fa32cells : implications for predicting human acute toxicity. P.J. Dierickx.  Toxicol. in Vitro,  2003, 17,  , 797-801 6.   Improved prediction of the human acute toxicity by the delayed cytotoxicity of the MEIC reference chemicals in Fa32 cells. P.J. Dierickx  Toxicol. Lett. ,  2003, 144,  (S1), s48 7.   Cystathionine pathway-dependent cytotoxicity of diethyl maleate and diamide in Fa32 and Hep G2 cells. P.J. Dierickx  Toxicol. Lett.,  2003, 144,  (S1), s119 8.   Comparison of the cytotoxicity of the MEIC reference chemicals measured in PBS and in complete medium. P.J. Dierickx  21st Annual SSCT Workshop on In Vitro Toxicology, Murikka, Finlan; Book of abstracts,  2003, ,  , p.52 9.   Cytotoxicity of the dicarboximide fungicides vinclozolin and iprodione in Fa32 cells P.J. Dierickx  21st Annual SSCT Workshop on In Vitro Toxicology, Murikka, Finland; Book of abstracts,  2003, ,  , p.51 10.   Toxicological evaluation of Haine river waste-water samples in sensitised cultured FHM fish cells compared with the microtox method. P.J. Dierickx and C.Van der Wielen  18th ESACT Meeting: Animal Cell Technology meets Genomics, Granada, Spanje; Book of abstracts,  2003, ,  , P-1.44 11.   Glutathione-dependent cytotoxicity of sodium fluoroacetate in rat and human hepatoma-derived cell cultures. P.J. Dierickx  Annual Congress of the British Toxicology Society, Edinburgh, Schotland; Book of abstracts,  2003, ,  , p. 68 12.   Toxicological evaluation of waste-water samples to appropiately sensitized cultured fathead minnow cells compared to the Microtox assay. E.M. Scheers, C. Van der Wielen and P.J. Dierickx  Bull. Environ. Contam. Toxicol. ,  2002, 68,  , 253-260 13.   Glutathione S-transferase isoenzymes in the two-spot ladybird, Adalia bipunctata (Coleoptera : Coccinnelidae). F. Francis, E. Haubruge and P. Dierickx  Arch. Insect Biochem. Physiol.,  2002, 49,  , 158-166 14.   Cystathione Pathway-dependent cytotoxicities of diethyl maleate and diamide in rat and human hepatoma-derived cell cultures. P.J. Dierickx, J.O. De Beer and E.M. Scheers  Alt. Lab. Anim.,  2002, 30,  , 61-68 15.   Cytotoxicity of amino alcohols to rat hepatoma-derived Fa32 cells. E.M. Scheers, A. Forsby and P.J. Dierickx  Altern. Lab. Anim.,  2002, 30,  , 309-312 16.   Neutral red uptake inhibition in adhered and adhering rat hepatoma-derived Fa32 cells to predict human toxicity. P.J. Dierickx and E.M. Scheers  J. Appl. Toxicol.,  2002, 22 ,  , 61-65 17.   The effect of hexaaza- and hexathia-macrocyclic ligands on transition metal cytotoxicity in human hepatoma-derived cultured cells. P.W. Smet, T.F. Pauwels, P.J. Dierickx  Human and Experimental Toxicology,  2002, 21,  , 421-427 18.   Dithiothreitol toxicity and its activation of phase I and II enzymes in rat hepatoma-derived Fa32 cells. P.J. Dierickx and E.M. Scheers  Toxicology ,  2002, 178,  , 56-57 19.   Formation of ractive oxygen species in rat hepatoma-derived Fa32 cells to predict human toxicity. P.J. Dierickx  Toxicol. In Vitro,  2002, 16,  , 725-730 20.   Cytotoxicity in adhered and adhering rat hepatoma-derived Fa32 cells to predict human toxicity. P.J. Dierickx and E.M. Scheers.  12th International Workshop on In Vitro Toxicology, Formia (Italy); Book of abstracts,  2002, ,  , PB-03 21.   Correlation between the delayed cytotoxicity of the MEIC reference chemicals and human acute toxicity. P.J. Dierickx  12th International Workshop on In Vitro Toxicology, Formia (Italy); Book of abstracts,  2002, ,  , PB-02 22.   The prediction of human acute toxicity by the formation of reactive oxygen species in rat hepatoma-derived Fa32 cells. P.J. Dierickx  Joint meeting of the European Tissue Culture Society, the Scandinavian Society for Cell Toxicology and the British Prostate Group : Human Cell Culture 2002, Oxford, Engeland; Book of abstracts,  2002, ,  , 23.   Correlation between the delayed cytotoxicity of the MEIC reference chemicals in Fa32 cells and human acute toxicity. P.J. Dierickx  Beltox annual meeting 2002 : Current trends in chemical risk assessment, Brussel; Book of abstracts,  2002, ,  , P-15 24.   Novel advanced in vitro methods for long-term toxicity testing. The report and recommendations of ECVAM workshop 45. W. Pfaller, M. Balls, R. Clothier, S. Coecke, P. Dierickx, B. Ekwall, B.A. Hanley, T. Hartung, P. Prieto, M.P. Ryan, G. Schmuck, D. Sladowski, J.A. Vericat, A. Wendel, A. Wolf and J. Zimmer.  Alt. Lab. Anim.,  2001, 29,  , 393-426 25.   Long-term in vitro toxicity of 27 MEIC chemicals on HepG2 cells. E.M. Scheers, Ba. Ekwall and P.J. Dierickx  Alt. Lab. Anim. ,  2001, 29,  , 279-299 26.   Cytotoxicity of the MEIC reference chemicals in anti-oxidant enriched rat hepatoma-derived Fa32 cells. P.J. Dierickx, C. Smit and E.M. Scheers  Alt. Lab. Anim. ,  2001, 29,  , 217-223 27.   Cytotoxicity of the MEIC reference chemicals in cultured rat hepatoma-derived Fa32 cells. P.J. Dierickx  Hum. Exp. Toxicol.,  2001, 20,  , 56 28.   In vitro long-term cytotoxicity testing of 27 MEIC chemicals and comparison with acute human toxicity data. E.M. Scheers, Ba. Ekwall and P.J. Dierickx  Toxicol. In vitro ,  2001, 15,  , 153-161 29.   Activation of soluble glutahione transferase in rat hepatoma-derived Fa32 cells by several pesticides and oxidants P.J. Dierickx  Chem. Biol. Inter.,  2001, 133,  , 342-344 30.   Partial purification of the soluble glutathione S-transferase of two aphid species, Alaucorthum solani and Acyrthosiphon pisum. F. Francis, E. Haubruge, CH. Gaspar and P.J. Dierickx  Chem. Biol. Inter. ,  2001, 133,  , 268-270 31.   Glutathione S-transferase of Aulacorthum solani and Acyrthosiphon pisum : partial purification and characterization. F. Francis, E. Haubruge, CH Gaspar and P.J. Dierickx  Comp. Biochem. Physiol. ,  2001, 129B ,  , 165-171 32.   Neutral red uptake inhibition in rat hepatoma-derived Fa32 cells to predict human toxicity. P.J. Dierickx  Toxicol. Lett.,  2001, 123 ,  (S), 18 33.   Evaluation toxicologique d'échantillons d'eau de décharge dans les cellules FHM de poisson et comparaison avec la méthode Microtox E.M. Scheers, C. Van der Wielen and P.J. Dierickx  Colloque de la Société de Pharmaco-Toxicologie cellulaire; ,  2001, ,  P.31, 34.   Cytotoxicity of pyrethroid insecticides in rat hepatoma derived Fa32 cells. P.J. Dierickx, C. Smit and E.M. Scheers  Animal Cell Technology: from Target to Market; E. Lindner-Olssen, N. Chatzissavidou and E. Lüllau, Eds.; Kluwer Academic Publishers; Dordrecht, Boston, London,  2001, ,  , 266-268 35.   Evaluación toxicólogia de muestra de aguas residuales en cultivos sensibles de celulas de pescado FHM comparados con el methódo microtox. E.M. Scheers, C. Van der Wielen and P.J. Dierickx  Alternativas 2001. Primer taller sobre metódos alternativos a la experimentación animal en America Latina y el Caribe, Santiage de Cuba, Cuba, Book of abstracts,  2001, ,  , p.5 36.   Cytotoxicity of aminoalcohols in Fa32 cells. E.M. Scheers and P.J. Dierickx  19th annual SSCT scientific meeting, Ringsted, Denenmarken; Book of abstracts,  2001, ,  , 37.   Toxicity and cytotoxicity of wastewaters using V. fischeri and P. Promelas fish cells. C. Van der Wielen, I. Halleux, P.J. Dierickx and E.M. Scheers  10th International Symposium on Toxicity Assessment, Québéc, Canada, Book of Abstracts,  2001, ,  , p 42-43 38.   Cytotoxicity of synthetic pyrethroid insecticides in rat hepatoma-derived Fa32 cells. P.J. Dierickx, C. Smit and E.M. Scheers  17th ESACT Meeting: from Target to Market, Tylösand, Zweden; Book of abstracts,  2001, ,  , p. 173 39.   Toxicological evaluation of surface-water samples in sensitised cultured fish cells compared with the Microtox Method. P.J. Dierickx, C. Van der Wielen and S. Lemaire  Alt. Lab. Anim. ,  2000, 28,  , 509-515 40.   Cytotoxicity of the MEIC reference chemicals in rat hepatoma-derived Fa32 cells. P.J. Dierickx  Toxicology ,  2000, 150,  , 159-169 41.   Effect of solubility, pH and isoforms on the acute cytotoxicity of chemicals. E.M. Scheers and P.J. Dierickx.  Arch. Physiol. Biochem. ,  2000, 110,  , B15 42.   Glutathione-dependent cytotoxicity of some chloroacetanilide herbicides in hepatoma-derived cultured cells. P.J. Dierickx  4th Xenobiotic Metabolism and Toxicity Workshop of Balkan countries, Antalya, Turkije ; Book of abstracts ,  2000, ,  , 69 43.   Neutral red uptake inhibition by the MEIC reference chemicals in antioxidant enriched Fa32 cells. P.J. Dierickx, C.Smit and E.M. Scheers  18th SSCT Annual workshop on in vitro toxicology, Sollentuna, Zweden ; Book of abstracts,  2000, ,  , 4 44.   In vitro long-term cytotoxicity of 27 chemicals on Hep G2 cells and comparison with acute human toxicity data. Scheers E.M. Ba. Ekwall and Dierickx P.J.  18th SSCT Annual workshop on in vitro toxicology, Sollentuna, Zweden ; Book of abstracts ,  2000, ,  , 7 45.   Activation of soluble glutathione transferase in rat hepatoma-derived Fa32cells by several pesticides and oxidants. P.J. Dierickx  GST 2000 : International Conference on Glutathione Transferases, Uppsala, Zweden ; Book of abstracts,  2000, ,  , 114-115 46.   In vitro long-term cytotoxicity of 27 MEIC chemicals on HepG2 cells compared to their acute human toxicity. E.M. Scheers, Ba Ekwall and P.J. Dierickx  11th International Workshop on in vitro toxicology, Acantilado, Spanje ; Book of abstracts ,  2000, ,  , P5-04 47.   Cytotoxicity of the MEIC reference chemicals in Fa32 cells. P.J. Dierickx   11th International Workshop on in vitro toxicology, Acantilado, Spanje ; Book of abstracts ,  2000, ,  , P1-02 48.   Cytotoxicité des substances de reference MEIC dans les cultures de cellules Fa32 dérivées d’un hépatome de rat. P.J. Dierickx   Congrès SFT-SPTC : “thérapie cellulaire: aspects pharmacologiques, toxicologiqueset règlementaire”, Paris, Frankrijk ; Book of abstracts,  2000, ,  , P5 49.   Toxicity of phenethylisothiocyanate and dithiothreitol on Fa32 cells. E.M. Scheers and P.J. Dierickx  Fourth World Congress on Alternatives and Animal Use in the Life Sciences, New Orleans, USA; Book of abstracts ,  , 2002,  , p. 228 Reports:   1.   Collaborative study on the evaluation of alternative methods to the eye irritation test G.A.JACOBS and P.DIERICKX  REF:  , 1991

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